Naloxone only works if you already have opioids in your body like heroin or Oxycontin. Once administered, Naloxone works fast! It can reverse the effects of an opioid overdose within three to seven minutes. But it also needs to be given fast if someone is having an opioid overdose. Sometimes you need to use more than one dose of naloxone to reverse an opioid overdose. Don’t worry, you can’t overdose on naloxone.

Naloxone reverses the effect of the opioids the person is overdosing on. In some cases, this can cause them to go into opioid withdrawal.