Types of Naltrexone
Naltrexone is available in several forms, described below.
Injectable Naltrexone
Naltrexone is available in an injectable form that is delivered into the muscles. The form of naltrexone is long-lasting and is given once per month.
It is approved for treating both opioid use disorder and alcohol use disorder. Injectable naltrexone is available under the brand name Vivitrol.
Oral Naltrexone
The oral version of naltrexone is a pill that is generally taken once per day. Some patients take a larger dose of oral naltrexone every other day, or in some cases, every three days.
Talk with your doctor about the best dosing schedule for your needs. The oral form of naltrexone is marketed under the brand name ReVia.
How Naltrexone Works
Over time, naltrexone can reduce the association of alcohol and pleasure in your brain. This changes the brain’s reward pathways so that you can moderate or stop drinking altogether.
If you’ve had pleasurable experiences drinking alcohol in the past, your brain can associate those pleasurable experiences with alcohol. Similar associations occur when eating food or having sex.
It motivates us to continue these behaviors for survival. The same area of the brain responsible for associating pleasure with these activities is responsible for forming habits. Repeated activation of this region of the brain through alcohol creates a “positive reinforcement,” which results in the brain forming an intense desire, or craving, for these substances.
Naltrexone blocks the receptors in your brain that trigger the pleasurable feeling that drinking brings. You’ll still feel the effects of alcohol such as bad coordination and judgment, but you won’t experience the “buzz.”
It reduces the desire to keep drinking. For many people, this translates into having fewer drinks and subsequently drinking less overall. Over time, the desire to drink and cravings for alcohol can be eliminated.
Naltrexone has been shown to be effective by many studies, but it’s not a magic pill and it doesn’t work for everyone. Medication adherence, or taking the medications as prescribed, is extremely important for naltrexone to work as intended.
Even missing a single dose by accident or feeling the effects of alcohol can make it less effective. Confidant providers and recovery coaches can help you develop strategies to stick to your naltrexone plan. This can sometimes involve support from a loved one.
Read More: When is the Best Time to Take Naltrexone?
Why Choose Naltrexone for Alcohol Use Disorder
Other medications can help you cut back on alcohol consumption, but naltrexone has been effective and has a good safety record. Some of its advantages are as follows:
Effective
Naltrexone has been studied to help reduce alcohol consumption in 30+ clinical trials over a 20 year period and has consistently shown positive results, especially in reducing the amount of drinking.
Proven Safety Profile
Naltrexone has been prescribed for over 30 years and has been effective for a wide range of people. Side effects from naltrexone are rare.
Accessible
You can use naltrexone as needed to reduce your drinking. Naltrexone is also safe for use by people with or without other conditions such as hypertension, type 2 diabetes, or dyslipidemia.
Who Benefits from Naltrexone Treatment?
You don’t need to have a medical condition or an addiction to want to change your relationship with alcohol. Naltrexone can help you moderate or quit drinking. While naltrexone does not work for everyone, it is shown to be effective in reducing drinking for most people.
The effectiveness of naltrexone can decrease when it is not taken as prescribed. Confidant providers and coaches can help you develop a plan to stick to your plan with naltrexone.
Naltrexone can be taken in combination with some of the other medications for alcohol use disorder but cannot be taken in combination with the other medications for opioid use disorder (methadone and buprenorphine) or with prescription pain medications or illicit opioids. Taking naltrexone with opioids can cause sudden and severe withdrawal symptoms.
Naltrexone is not recommended for use in pregnancy. Naltrexone should not be used if you have a serious liver condition as the drug is metabolized in the liver.
To make sure naltrexone is right for you, you should disclose all important medical information to your Confidant provider. Initial prescription, as well as dosage adjustments should be monitored for side effects and potential effects on pre-existing conditions.